Monday 28, Sep 2009
Steroids and sports combining better than ever
Despite protests and outcries from members of sporting confederations and sportsmen, the relationship between sports and steroids is getting better than ever with more and more sportsmen making use of steroids than in the past.
While some people say that steroids are harmful to the human bodies, the truth is often kept hidden and the truth is that steroids do not bring any side effects with them, unless the steroid user starts abusing steroids.
From Entertainment.howstuffworks.com:
Anabolic Steroids
A steroid is a chemical substance derived from cholesterol. The body has several major steroid hormones — cortisol and testosterone in the male, estrogen and progesterone in the female. Catabolic steroids break down tissue, and anabolic steroids build up tissue. Anabolic steroids build muscle and bone mass primarily by stimulating the muscle and bone cells to make new protein.
Athletes use anabolic steroids because they increase muscle strength by encouraging new muscle growth. Anabolic steroids are similar in structure to the male sex hormone, testosterone, so they enhance male reproductive and secondary sex characteristics (testicle development, hair growth, thickening of the vocal cords). They allow the athlete to train harder and longer at any given period.
Anabolic steroids are mostly testosterone (male sex hormone) and its derivatives. Examples of anabolic steroids include:
* Testosterone
* Dihydrotestosterone
* Androstenedione (Andro)
* Dehydroepiandrosterone (DHEA)
* Clostebol
* Nandrolone
By having a close look at the above points, it can be clearly concluded that anabolic steroids are exceptional products that helps in building lean muscle mass besides brining favorable changes in body mass and function.
Posted in Steroids | 1 Comment/Questions
Thursday 24, Sep 2009
Corticosteroids aid faster recovery for pneumonia
Patients suffering from pneumonia can recover more quickly with a combination of corticosteroids and traditional antimicrobial therapy, as per scientists from the UT Southwestern Medical Center.
It is noteworthy to remember here that Corticosteroids are generally used to treat inflammation in relevance to infectious disease unlike anabolic steroids that are used to bulk muscles.
In a study available online, researchers at UT Southwestern remarked that mice infected with a certain type of severe bacterial pneumonia and treated with a combination of steroids and antibiotic therapy experience quicker recovery with less inflammation than a mice treated only with antibiotics.
From News-Medical.Net:
“Some people might think that if you give steroids, it would counteract the effect of the antibiotic,” said Dr. Robert Hardy, associate professor of internal medicine and pediatrics and the study’s senior author. “But it turns out you need the antibiotic to kill the bug and the steroid to make the inflammation in the lung from the infection get better. The steroids don’t kill the bugs, but they do help restore health.”
Pneumonia is a lung infection typically characterized by breathing difficulties and spread by coughing and sneezing. Symptoms include headache, fever, chills, coughs, chest pain, sore throat and nausea. Pneumonia caused by the Mycoplasma pneumoniae bacterium is generally a less severe form of the disease that can occur in any age group. It accounts for 20 percent to 30 percent of all community-acquired pneumonia cases.
In the current study, mice infected with the M pneumoniae bacterium were treated daily with a placebo, an antibiotic, a steroid, or a combination of the antibiotic and steroid in order to investigate the effect on M pneumoniae-induced airway inflammation. The animals were then evaluated after one, three and six days of therapy.
“It turns out that the group that got both the antibiotic and the steroids did the best,” Dr. Hardy said. “The inflammation in their lungs got significantly better.”
It was remarked by Dr. Hardy that it is still very early to recommend steroids as a form of standard treatment for patients suffering from this kind of bacterial pneumonia, but he also remarked that the work does support the need for a clinical trial.
Posted in Steroids | 1 Comment/Questions
Sunday 20, Sep 2009
Relationship between sound sleep in infancy and likelihood of drug abuse in teenage
As per a recent surprising finding made by a University of Michigan Health System team, there is an underlying relationship between sleeping problems in toddler years and the probability of using alcohol, cigarettes, and drugs (marijuana, inhalants, cocaine, steroids, and other illicit drugs) early in teen years. These findings were revealed by the involved team as part of a family health study that followed 257 boys and their parents for 10 years.
It was also remarked during the study that teens whose preschool sleeping patterns were poor were more likely to use alcohol, drugs, or tobacco than their counterparts who enjoyed good sleep schedules.
From News-medical.net:
“What’s so interesting about this finding is that the effect exists regardless of a number of other factors that previously had been identified as relating to risk for substance use and abuse,” says senior author and UMARC director Robert Zucker, Ph.D. “It appears to indicate some shared neurobiological dysfunction whose details we don’t yet know. Further studies will be crucial to our understanding.”
“Taken together with other studies in this area, our findings help make up a chain of evidence linking sleep disturbances to alcohol problems across a large segment of the life span,” says lead author and research assistant professor Maria Wong, Ph.D.
The finding does not mean there’s a cause-and-effect relationship, notes co-author and psychiatry professor Kirk Brower, M.D., who has studied the interplay of alcohol and sleep in adults, and is Executive Director of the Chelsea Arbor Treatment Center, which treats teen and adult substance abusers. (Chelsea Arbor is a joint program of U-M and Chelsea Community Hospital.)
“Our finding sees early childhood sleep disturbances as a marker, or predictor, for early use of drugs and alcohol in adolescence, not a predetermined trajectory,” he says. “But for parents, this is one more reason to take your child’s sleep problems seriously, not to dismiss them, and to talk with your child’s pediatrician or family doctor.”
It was remarked by Wong that parents need to be more cautious and attentive to complaints raised by their wards regarding overtiredness and insomnia. It was also remarked that a regular sleep schedule and ongoing discussions with a health care provider can go a long way in ensuring balanced care and development of the young minds.
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Wednesday 16, Sep 2009
Patients suffering from seasonal allergic rhinitis finally get a relief
The results of a new Creighton University study may soon be spelling relief for as many as 40 million Americans who have been suffering from seasonal allergic rhinitis (SAR) caused by pollens such as grass and ragweed.
It was remarked during the study that noninhaled, intranasal carbon dioxide (CO2) can provide an effective treatment for many SAR sufferers.
Thomas B. Casale, M.D., principal investigator and chief of Creighton School of Medicine’s Division of Allergy/Immunology was of the view that the findings of this study can be hailed as amicable alternative for people who are not very keen to take up intranasal steroids.
From News-Medical.Net:
In the Creighton study, patients receiving CO2 reported a significant and rapid improvement in congestion, sneezing and other nasal symptoms – within 10 minutes and lasting at least 24 hours – over those taking a placebo (plain air). The CO2 group also reported some, although not statistically significant, improvement in non-nasal symptoms such as watery and itchy eyes.
Within 30 minutes of treatment, 50 percent of those taking CO2 reported more than a 50 percent improvement in nasal symptoms, compared to 27.6 percent of the placebo group.
The Creighton study involved 89 subjects, 18 to 75 years of age, who had at least a two-year history of seasonal allergies requiring pharmacotherapy. Sixty received CO2 and 29 received plain air.
The patients took the gases intranasally twice – once for each nostril – within an interval of less than five minutes for a total dose of about 1,200 milliliters. They avoided inhaling the gas by breathing through the mouth, allowing the gas to flow in one nostril, pass through the nose and sinus cavities, and pass out the other nostril.
It is critical to note here that intranasal noninhaled CO2has proved to be an efficacious option for treating migraine despite the fact that the FDA is yet to grant its approval for this type of a use.
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Sunday 13, Sep 2009
HIV Patients treated with anabolic steroids can gain muscle size and weight gains
HIV Patients who have been treated with anabolic steroids for preventing AIDS Wasting can feel modest gains in the terms of muscle size and weight according to a medical review that was published in an issue of The Cochrane Library, a publication of The Cochrane Collaboration.
The enormity of experienced gains can be termed to be relevant in clinical terms, as per review’s lead author Karen Johns, a Medical Assessment Officer from the Agency Health Canada.
From News-Medical.Net:
Anabolic steroids are synthetic substances similar to the male sex hormone testosterone that promote growth of skeletal muscle and the development of male sexual characteristics.
Although most recently in the news for their misuse by professional athletes, anabolic steroids have legitimate medical application for men with low testosterone and people with certain types of anemia. Two anabolic steroids available in the United States, nandrolone decanoate and oxandrolone, have been used to help increase weight and muscle mass in small studies of people with wasting.
Conversely, anabolic steroid use has been associated with increased rates of HIV in those who share needles or use nonsterile needles when they inject steroids.
In the review studies, anabolic steroids were administered to patients either orally or by injection. The main side effects were mild and included abnormal liver function tests; acne; mild increase in body hair; breast tenderness; increased libido, aggressiveness and irritability; and mood swings — all common side effect of anabolic steroid use.
“The risks and side effects of taking anabolic steroids long-term are certainly of concern,” Johns said. “We were unable to assess these risks in our review due to the short duration of treatment in the studies.”
AIDS Wasting is a result of low testosterone and lost ability of the human body to promote muscle growth. This review is expected to offer a new paradigm for providing relief to patients with HIV.
Posted in Steroids | 1 Comment/Questions
Tuesday 08, Sep 2009
Clemens versus McNamee, legal battle to continue in New York
In January 2008, Roger Clemens initially filed a case against his former personal trainer, Brian McNamee in Texas. The pitcher claimed that McNamee’s statements, which he made in the Mitchell report and in Sports Illustrated’s website, were untrue and defamatory.
Last August 28, 2009, US District Judge Keith P. Ellison dismissed the remainder of the case. Aside from this, Clemens cannot refile his case in the state of Texas. However, he plans to make an appeal in the US 5th Circuit Court of Appeals to review the judge’s decision.
Brian McNamee filed a defamation suit in July 31 in defense of Clemens’ allegations. According to McNamee, Clemens’ refusal of his statement was an intense and coordinated public relations offensive.
Clemens appeared on “60 minutes” to hold a nationally televised news conference against McNamee.
McNamee’s statement claimed that he injected Clemens with anabolic steroids and human growth hormone at least 16 times in 1998, 2000 and 2001.
McNamee’s lawyer, Richard Emery, thinks that the move of their legal battle from Texas to New York would prove to be an advantage on their part.
Emery added that the most important battle is still in Washington, DC where the Justice Department was asked by the congressional committee to launch a probe as to whether Clemens lied.
From Google Hosted News:
NEW YORK — The remainder of Roger Clemens’ defamation suit against Brian McNamee in Texas has been dismissed, leaving the pair to fight their legal battle in New York.
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Wednesday 02, Sep 2009
Incidence of rejection gets increased with early steroid withdrawal
A study indicated that a high incidence of rejection and a low incidence of intolerance is related to an early steroid withdrawal following liver transplantation. The study, which is hailed as the first-of-its-kind double-blind placebo-controlled study, was undertaken to examine effects of early steroid elimination.
The study results were published in an issue of Liver Transplantation, the official journal of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Transplantation Society (ILTS).
From Eurekalert.org:
The normal course of treatment after liver transplantation includes calcineurin inhibitors (a class of immunosuppressants) and steroids to minimize rejection and improve survival rates, but the long-term complications of these drugs can be fatal. Steroid use in particular can lead to diabetes, high cholesterol and hypertension, which increase the risk of heart disease, and can lead to death. Several previous studies have reported that early withdrawal from steroids reduced the incidence of these side effects, but that rejection increased, although it could be controlled with steroid pulse therapy (in which high doses of steroids are administered intravenously for a short period of time). The current multicenter study was the first prospective double-blind, placebo-controlled trial to compare early steroid withdrawal with continued use.
Led by Georges-Philippe Pageaux, of the Centre Hospitalier University St.-Eloi in Montpellier, France, the study examined 174 patients in 15 French liver transplantation centers over a 14-month period from December 1999 to August 2001. The patients were randomly divided into two groups seven days following transplant: 90 of them continued to receive steroids for six months, while 84 received a placebo starting at day 14 (following 7 days of tapering from steroids). At the end of six months, 22 patients in the steroid group (24.4 percent) and 32 patients in the placebo group (38.1 percent) experienced acute rejection. Although there was no statistical difference in the two groups for high cholesterol and hypertension, 22.2 percent of patients in the steroid group developed diabetes compared with 14.3 percent of placebo patients. At the end of 12 months, the incidence of acute rejection was 25.6 percent in the steroid group versus 39.3 percent in the placebo group, but there no longer a difference in diabetes between the two groups.
The involved authors were of the view that early steroid withdrawal at day 14 cannot be termed as safe when it comes to rejection but told that it is efficient in terms of tolerability to glucose.
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